Selected Publications

Cheruiyot AC, Hollister-Lock J, Sullivan B, Pan H, Dreyfuss JM, Bonner-Weir S, Schaffer JE. Sustained hyperglycemia specifically targets translation of mRNAs for insulin secretion. J Clin Invest. 2023 Nov 30:e173280. doi: 10.1172/JCI173280. Online ahead of print.PMID: 38032734

Sletten AC, Davidson JW, Yagabasan B, Moores S, Schwaiger-Haber M, Fujiwara H, Gale S, Jiang X, Sidhu R, Gelman S, Zhao S, Patti G, Ory DS, Schaffer JE. Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis. Nature Comm 2021, DOI 10.1038/s41467-021-25457-y. PMID 34471131, PMCID: PMC8410784

Krishnan K, Qian M, Feltes M, Chen ZW, Gale S, Wang L, Sugasawa Y, Reichert D, Schaffer JE, Ory D, Evers A, Covey D. Validation of trifluoromethylphenyl diazirine photoaffinity analogues of cholesterol and application as photolabling reagents for the pentameric ligand-gated ion channel GLIC. ACS Chemical Biology 2021, 16: 1493-1507.  PMID 3435583, PMCID pending

Schaffer JE. Death by lipids: the role of small nucleolar RNAs in metabolic stress. J Biol Chem 2020, 295: 8628-8635. PMCID: PMC7307203

Peterson LR, Jiang X, Chen L, Goldberg AC, Farmer MS, Ory DS, Schaffer JE. Alterations in plasma triglycerides and ceramides: links with cardiac function in humans with type 2 diabetes. J Lipid Res 2020, May 11:jlr.RA120000669. doi: 10.1194/jlr.RA120000669. Online ahead of print. PMID: 32393551 

Feltes M, Gale SE, Moores S, Ory DS, Schaffer JE. Monitoring the itinerary of lysosomal cholesterol in Niemann-Pick C-deficient cells after cyclodextrin treatment. J Lipid Res 2020, 61: 1065-1074. PMCID: PMC7328042

Sidhu R, Kell P, Dietzen D, Farhat N, Do AD, Porter F, Berry-Kravis E, Vite C, Reunert J, Marquardt T, Giugliani R, Lourenco C, Bodamer O, Plummer E, Wang R, Schaffer JE, Ory DS, Xiang J. Application of N-Palmitoyl-O-Phosphocholineserine for Diagnosis and Assessment of Response to Treatment in Niemann-Pick Type C disease. Mol Gen Metab 2020, 129: 292-302. PMCID: PMC7145728

Cresci S, Zhang R, Yang Q, Duncan MS, Xanthakis V, Jiang X, Ramachandran SV, Schaffer JE, Peterson LR. Genetic architecture of the circulating very long-chain (C24:0 and C22:0) ceramide concentrations. J Lipid Athero 2020, 9: 172-183. PMCID: PMC7266332

McGrath ER, Himali JJ, Xanthakis V, Duncan MS, Schaffer JE, Ory DS, Peterson LR, DeCarli C, Pase, MP, Satizabal CL, Vasan RS, Beiser AS, Seshadri S. Circulating ceramide ratios and risk of vascular brain aging and dementia. Ann Clin Transl Neurol 2020, 7: 160-168. PMCID:PMC7034495

Sidhu R, Mondjinou Y, Qian M, Song H, Kumar AB, Hong X, Hsu FF, Dietzen DJ, Yanjanin NM, Porter FD, Berry-Kravis E, Vite CH, Gelb MH, Schaffer JE, Ory DS, Jiang X. N-acyl-O-phosphocholineserines: structures of a novel class of lipids that are biomarkers for Niemann-Pick C1 disease. J Lipid Res 22019, 60: 1410-1424. PMCID: PMC6672039

Davidson J, Molitor E, Moores S, Gale SE, Subramanian K, Jiang X, Sidhu R, Kell P, Zhang J, Fujiwara H, Davidson C, Helquist P, Melancon BJ, Grigalunas M, Liu G, Salahi F, Wiest O, Xu X, Forbes DP, Pipalia NH, Cruz DL, Holson EB, Schaffer JE, Walkley SU, Maxfield FR, Ory DS. 2-hydroxypropyl-b-cyclodextrin is the active component in a triple combination formulation for treatment of Niemann-Pick C1 Disease. Biocehim Biophys Acta 2019, 1864: 1545-1561. PMCID: PMC6679735

Feltes M, Moores S, Gale SE, Krishnan K, Mydock-McGrane L, Covey DF, Ory DS, Schaffer JE. Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking. J Lipid Res 2019, 60:707-716. PMCID: PMC6399506

Jiang X, Sidhu R, Orsini JJ, Farhat NY, Porter FD, Berry-Kravis E, Schaffer JE, Ory DS. Diagnosis of Niemann-Pick C1 by measurement of bile acid biomarkers in archived newborn dried blood spots. Mol Gen Metab 2019, 126:183-187. PMCID: PMC6365165

Goldberg IJ, Reue K, Abumrad NA, Bickel PE, Cohen S, Fisher EA, Galis ZS, Granneman JG, Lewandowski ED, Murphy R, Olive M, Schaffer JE, Schwartz-Longacre L, Shulman GI, Walther TC, Chen J. Deciphering the role of lipid droplets in cardiovascular disease: a report from the 2017 National Heart, Lung, and Blood Institute workshop. Circulation 2018, 138: 305-315. PMCID: PMC6056021

Sletten AC, Peterson LR, Schaffer JE. Manifestations and mechanisms of myocardial lipotoxicity in obesity. J Internal Med 2018, 284: 478-491. PMCID: PMC6045461

Rimer JM, Lee J, Holley CH, Crowder RJ, Chen DL, Hanson PI, Ory DS, Schaffer JE. Long-range function of secreted small nucleolar RNAs that direct 2¢-O-methylation. J Biol Chem 2018, 293: 13284-13296. PMCID: PMC6109910

Selected by editors as the RNA paper most emblematic of outstanding discoveries across JBC’s scientific scope and included in “The Year in JBC: 2018”

Peterson LR, Xanthakis V, Duncan MS, Gross S, Friedrich N, Volzke H, Felix SB, Jiang H, Sidhu R, Nauck M, Jiang X, Ory DS, Dorr M, Vasan RS†, Schaffer JE†. Ceramide remodeling and risk of cardiovascular events and mortality. J Am Heart Assoc 2018;7(10). pii: e007931. doi: 10.1161/JAHA.117.007931. PMCID: PMC6015315 († co-corresponding author)

Sidhu R, Mikulka CR, Fujiwara H, Sands MS, Schaffer JE, Ory DS, Jiang X. A HILIC-MS/MS method for simultaneous quantification of the lysosomal disease markers galactosylsphingosine and glucosylsphingosine in mouse serum. Biomed Chrom 2018, 32: e4235. PMCID: PMC5992066

Tsushima K, Bugger H, Wende AR, Soto J, Jenson GA, Tor AR, Hu XX, Sloan CL, Spitzer KW, Sharp TL, Shoghi K, Khalimonshuk O, Amiott EA, Shaw JM, Schaffer JE, Abel ED. Mitochondrial reactive oxygen species in lipotoxic hearts induces post-translational modifications of AKAP121, DRP1, and OPA1 that promote mitochondrial fission. Circ Res 2018, 122: 58-73. PMCID: PMC5756120

Li MW, Sletten A, Lee J, Pyles KD, Matkovich SJ, Ory DS, Schaffer JE. Nuclear export factor 3 regulates localization of small nucleolar RNAs. J Biol Chem 2017, 292:20228-20239. PMCID: PMC5724009

Mikhalkova D, Holman SR, Jiang H, Saghir M, Novak E, Coggan AR, O’Connor R, Bashir A, Jamal A, Ory DS, Schaffer JE, Eagon C, Peterson LR. Gastric bypass surgery-induced cardiac and lipidomic alterations in women with heart failure with preserved ejection fraction (HFpEF). Obesity 2018, 26:284-290. PMCID: PMC5783730

Jackson CE, Scruggs BS, Schaffer JE, Hanson PI. Effects of inhibiting VPS4 support a general role for ESCRTs in extracellular vesicle biogenesis. Biophys J 2017, 113: 1342-1352. PMCID: PMC5607042

New and notable. Castle JD. Separating pathways in the extracellular ESCRT service. Biophys J 2017, 113: 1179-80.

McCommis KS, Hodges WT, Brunt EM, Nalbantoglu I, McDonald WG, Holley C, Fujiwara, H, Schaffer JE, Colca JR, Finck BN. Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis. Hepatology 2017, 65: 1543-1556. PMCID: PMC5397348

Caputa G, Schaffer JE. RNA regulation of lipotoxicity and metabolic stress. Diabetes 2016, 65: 1816-1823. PMCID: PMC4915576

Lee J, Harris AN, Holley CL, Mahadevan J, Pyles KD, Lavagnino Z, Scherer DE, Fujiwara H, Sidhu R, Zhang J, Huang SCC, Piston DW, Remedi MS, Urano F, Ory DS, Schaffer JE. Rpl13a small nucleolar RNAs regulate systemic glucose metabolism. J Clin Invest 2016, 126: 4616-4625. PMCID: PMC5127695

Jiang X, Sidu R, Mydock L, Hsu F-F, Covey DF, Scherrer DE, Yanjanin-Farhat N, Porter FD, Dietzen DJ, Orsini JJ, Berry-Kravis E, Zhang X, Keutzer J, Reunert, Thorsten Marquardt J, Runz H, Schaffer JE, Ory DS. Development of a bile acid-based newborn screen for Niemann-Pick disease type C. Science Trans Med 2016, 8:337ra63. PMCID: PMC5316294

Airhart S, Cade WT, Jiang H, Coggan AR, Racette SB, Korenblat K, Spearie CA, Waller S, O’Connor R, Bashir A, Ory DS, Schaffer JE, Novak E, Farmer M Davila-Roman VG, Javidan-Nejad C, Peterson LR. A diet rich in medium-chain fatty acids improves systolic function and alters the lipidomic profile in patients with type 2 diabetes: a pilot study. J Clin Endo Metab 2016, 101: 504-512. PMCID: PMC4880128

Schaffer JE. Lipotoxicity: the many roads to cell dysfunction and cell death. J Lipid Res 2016, 57:1327-1328. PMCID: PMC4959852

Caputa G, Zhao S, Guerrero AE, Ory DS, Duncan JG, Schaffer JE. RNASET2 is required for ROS propagation during oxidative stress-mediated cell death. Cell Death Differ 2016, 23:347-357. PMCID: PMC4716297

Iaea DB, Gale SE, Bielska AA, Kathiresan K, Fujiwara H, Maxfield FR, Schlesinger PH, Covey DF, Schaffer JE, Ory DS. A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol. J Lipid Res 2015, 56: 2408-2419. PMCID: PMC4655980

Sidhu R, Jiang H, Yanjanin NM, Carasco-Carillo N, Woolery M, Ottinger E, Porter FD, Schaffer JE, Ory DS, Jiang X. A validated LC-MS/MS Assay for Quantification of 24(S)-hydroxycholesterol in plasma and cerebrospinal fluid. J Lipid Res 2015, 56: 1222-1223. PMCID: PMC4442878

Praggastis M, Tortelli B, Zhang J, Fujiwara H, Sidhu R, Chacko A, Chen Z, Lieberman AP, Davidson C, Walkley SU, Pipalia NH, Maxfield FR, Schaffer JE, Ory DS. A murine Niemann-Pick C1 (NPC1) I1061T knockin model recapitulates the pathological features of the most prevalent human disease allele. J Neuroscience 2015, 35: 8091-8106. PMCID: PMC4444535

Jinn S, Brandis KA, Ren, A, Chacko A, Dudley-Rucker N, Fujiwara H, Jiang H, Olsen BN, Schaffer JE, Ory DS. SnoRNA U17 regulates cellular cholesterol trafficking. Cell Metab 2015, 21: 855-867. PMCID: PMC4456254

Holley CL, Li MW, Scruggs BS, Matkovich SJ, Ory DS, Schaffer JE. Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase. J Biol Chem 2015, 290: 11741-11748. PMCID: PMC4416874

Bowler RP, Jacobson S, Cruickshank C, Hughes GJ, Siska C, Reisdorph N, Petrache I, Ory DS, Schaffer JE, Kechris K. Plasma sphingolipids associated with COPD phenotypes. Am J Resp Crit Care Med 2015, 191: 275-284. PMCID: PMC 4351578

Elezaby A, Sverdlov AL, Tu VH, Soni K, Qin F, Liesa M, Shirihai OS, Rimer J, Schaffer JE, Colucci WS, Miller EJ. Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload. J Mol Cell Cardiol 2015, 79:275-283. PMCID: PMC 4301992

Tortelli B, Bagel JH, Zhang J, Fujiwara H, Sidhu R, Jiang X, Yanjanin NM, Porter FD, Schaffer JE, Vite C, Ory DS. Cholesterol homeostatic responses provide biomarkers for monitoring cyclodextrin therapy in the neurodegenerative disease Niemann-Pick C1 (NPC1). 2014, Hum Mol Genet 2014, 23: 6022-6033. PMCID: PMC 4204776

Crawford PA, Schaffer JE. Metabolic stress in the myocardium: adaptations of gene expression. J Mol Cell Cardiol 2013, 55:130-138. PMCID: PMC3474866

Brandis KA, Jinn S, Langmade SJ, Dudley-Rucker N, Jiang H, Ren A, Goldberg A, Schaffer JE, Ory DS. Box C/D snoRNA U60 is required for intracellular cholesterol trafficking. J Biol Chem 2013, 288: 35703-35713. PMCID: PMC3861622

Fan M, Sidhu R, Fujiwara H, Tortelli B, Zhang J, Davidson C, Walkley SU, Bagel JH, Vite C, Yanjanin NM, Porter FD, Schaffer JE, Ory DS. Identification of plasma biomarkers for human Niemann-Pick C1 (NPC1) disease biomarkers through metabolomic profiling. J Lipid Res 2013, 54: 2800-2814. PMCID: PMC3770093

Jiang H, Fong-Fu H, Farmer MS, Peterson LR, Schaffer JE, Ory DS, Jiang X. Development and validation of an LC-MS/MS method for determination of very long acyl chain (C22:0 and C24:0) ceramides in human plasma. Anal Bioanal Chem 2013, 405:7357-7365. PMCID: PMC3766747

Li X, Gonzalez O, Shen X, Barnhart S, Kramer F, Kanter JE, Vivekanandan-Giri A, Tsuchiya K, Handa P, Pennathur S, Kim F, Coleman RA, Schaffer JE, Bornfeldt KE. Endothelial acyl-CoA synthetase 1 is not required for inflammatory and apoptotic effects of a saturated fatty acid-rich environment. Arterioscler Thromb Vasc Biol 2013, 33:232-240. PMCID: PMC3553857

Schilling JD, Machkovech H, He L, Sidhu R, Fujiwara H, Weber K, Ory DS, Schaffer JE. Palmitate and lipopolysaccharide trigger synergistic ceramide production in primary macrophages. J Biol Chem 2013, 288: 2923-2932. PMCID: PMC3561515

Schilling JD, Machkovech HM, He L, Diwan A, Schaffer JE. TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a TRIF-dependent pathway. J Immunol 2013, 190: 1285-1296. PMCID: PMC3552058

Schilling J, Machkovech H, Kim AHJ, Schwendener R, Schaffer JE. Macrophages modulate cardiac function in lipotoxic cardiomyopathy. Am J Physiol 2012, 303:  H1366-H1373. PMCID: PMC3532539. Erratum in: Am J Physiol Heart Circ Physiol. 2013, 304: H632 [corrected author name Schwendener R]

Peterson LR, McKenzie CR, Schaffer JE. Diabetic cardiovascular disease: getting to the heart of the matter. J Cardiovasc Trans Res 2012, 5: 436-445. PMCID: PMC3396765

Scruggs BS, Michel CI, Ory DS, Schaffer JE. SmD3 regulates intronic non-coding RNA biogenesis. Mol Cell Biol 2012, 32: 4092-4103. PMCID: PMC3457340

Article of Interest selected by the Editors

Michel CI, Holley, CL, Scruggs BS, Sidhu, R, Brookheart RT, Listenberger LL, Behlke M, Ory DS, Schaffer JE. Small nucleolar RNAs, U32, U33, and U35 are critical mediators of metabolic stress. Cell Metab 2011, 14: 33-44. PMCID: PMC3138526.

Preview. Mattijssen F, Kersten S. Saturated fatty acids and snoRNAs: partners in crime. Cell Metab 2011, 14: 1-2.

Jiang X, Sidhu R, Porter FD, Yanjanin NM, Speak A, te Vruchte DT, Platt FM, Dietzen DJ, Covey DF, Schaffer JE,Ory DS. A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma. J Lipid Res 2011, 52: 1435-1445. PMCID: PMC3122908.

Anderson CC, Gibson AA, Schaffer JE, Peterson LR, Holland MR, Miller JG. Bayesian parameter estimation for characterizing the cyclic variation of echocardiographic backscatter to assess the hearts of asymptomatic type 2 diabetes mellitus subjects. Ultrasound Med Biol 2011, 37: 805-812. PMCID: PMC3078972.

Ory DS, Schaffer JE. ApoA-1 in diabetes: damaged goods. Diabetes 2010, 58:2358-2359. PMCID: PMC3279547.

Porter FD, Scherrer DE, Lanier MS, Langmade SJ, Molugu V, Gale SE, Olzeski D, Sidhu R, Dietzen D, Wassif CA, Yanjanin NM, Marso SP, House J, Vite C, Schaffer JE, Ory DS. Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease. Science Trans Med 2010, 2:58ra81. PMCID: PMC3170139.

Holland MR, Gibson, AA, Bauer AQ, Peterson LR, Schaffer JE, Bach RG, Cresci S, Miller JG. Echocardiographic tissue characterization demonstrates differences in the left and right sides of the ventricular septum. Ultrasound Med Biol 2010, 36: 1653-1661. PMCID: PMC2942980.

Jungheim ES, Schoeller EL, Marquard KL, Louden ED, Schaffer JE, Moley KH. Diet-induced obesity model: abnormal oocytes and persistent growth abnormalities in the offspring. Endocrinology 2010, 151:4039-4046. PMCID: PMC2940512.

Brookheart RT, Michel CI, Schaffer JE. As a matter of fat. Cell Metabolism 2009, 20: 9-12. PMCID: PMC2751821

Liu L, Shi XJ, Bharadwaj KG, Ikeda S, Yamashita H, Yagyu H, Schaffer JE, Yu YH, Goldberg IJ.  DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity. J Biol Chem 2009, 284:36312-36323. PMCID: PMC2794747.

Gibson AA, Schaffer JE, Peterson LR, Roberts KM, Haider, TA, Bilhorn KR, Farmer M, Holland MR, Miller JG. Quantitative analysis of the magnitude and time delay of cyclic variation of myocardial backscatter from asymptomatic type 2 diabetes mellitus subjects. Ultrasound Med Biol 2009, 9: 1458-1467. PMCID: PMC2731824.

Brookheart RT, Michel CI, Listenberger LL, Ory DS, Schaffer JE. The non-coding RNA gadd7 is a regulator of lipid-induced oxidative and ER stress. J Biol Chem 2009, 284: 7446-7454. PMCID: PMC2658040

Flagg TP, Remedi MS, Haim TE, Tones, MA, Bahinski T, Numann R, Kovacs A, Schaffer JE, Nichols CG, Nerbonne JM. Ca2+-independent alterations in diastolic sarcomere length and relaxation kinetics in a mouse model of lipotoxic diabetic cardiomyopathy. Circ Res 2009, 104:95-103. 

Gale SE, Westover EJ, Merlin S, Scherrer DE, Han S, Xiuhong Z, Brockman HL, Brown RE, Covey DF, Schaffer JE, Schlesinger P, Ory DS. Side-chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions. J Biol Chem 2009 284:1755-1764. PMCID: PMC2615513.

Zhang J, Coleman T, Scherrer DE, Langmade SJ, Feng C, Sands M, Schaffer JE, Semenkovich C, Ory DS. Deficiency of an endogenous LXR ligand impairs cholesterol efflux and promotes atherosclerosis in a macrophage-restricted Niemann-Pick C1 (NPC1) loss of function model. J Clin Invest 2008, 118: 2281-2290. PMCID: PMC2381744.

Gelsthorpe ME, Baumann N, Millard E, Gale SE, Langmade SJ, Schaffer JE, Ory DS. NPC1 I1061T mutant encodes a functional protein that is selected for ER-associated degradation due to protein misfolding. J Biol Chem 2008, 283: 8229-8236.

O'Connor RD, Gropler RJ, Peterson L, Schaffer J, Ackerman JJ. Limits of a Localized Magnetic Resonance Spectroscopy Assay for Ex Vivo Myocardial Triacylglycerol. J Pharm Biomed Anal 2007, 45:382-389.

Peura JL, Schaffer JE. Lipotoxicity in cardiac and skeletal muscle. Heart and Metab 2006, 30: 4-6. 

Langmade SJ, Gale S, Frolov A, Mohri I, Suzuki K, Mellon S, Walkey S, Covey D, Schaffer JE, Ory DS. Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C Disease. Proc Natl Acad Sci USA 2006, 103: 13807-13812.

Borradaile NM, Han X, Harp JD, Ory DS, Schaffer JE. Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J Lipid Res 2006, 47: 2726-2737.

Holland MR, Gibson AA, Peterson LR, Areces M, Schaffer JE, Perez JE, Miller JG. Measurements of the cyclic variation of myocardial backscatter from two-dimensional echocardiographic images as an approach for characterizing diabetic cardiomyopathy. J Cardiometab Syndr 2006, 1: 149-152.

Lee Y, Naseem RH, Park BH, Garry DJ, Richardson JA, Schaffer JE, Unger RH. a-Lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice, Biochem Biophys Res Comm 2006, 344: 446-452.

Gale SE, Frolov A, Han X, Bickel PE, Cao L, Bowcock A, Schaffer JE, Ory DS. A regulatory role for 1-acylglycerol-3-phosphate-o-acyltransferase 2 in adipocyte differentiation. J Biol Chem 2006, 281: 11082-11089.

Richards MR, Harp JD, Ory DS, Schaffer JE. Fatty acid transport protein 1 and long chain acyl CoA synthetase 1 interact in adipocytes. J Lipid Res 2006, 47: 665-672.

Borradaile NM, Buhman KK, Listenberger LL, Magee CJ, Morimoto ETA, Ory DS, Schaffer JE. A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death. Mol Biol Cell 2006, 17:770-778.

Borradaile NM, Schaffer JE. Lipotoxicity in the heart. Curr Hypertens Rep 2005, 7: 412-417.

Millard EE, Gale S, Dudley N, Zhang J. Schaffer JE, Ory DS. The sterol-sensing domain of the Niemann-Pick C1 (NPC1) protein regulates trafficking of low-density lipoprotein cholesterol. J Biol Chem 2005, 280: 28581-28590.

Chiu HC, Kovacs A, Blanton RM, Han X, Courtois M, Weinheimer CJ, Yamada KA, Brunet S, Xu H, Nerbonne JM, Welch MJ, Fettig NM, Sharp TL, Sambandam N, Olson KM, Ory DS, Schaffer JE. Transgenic expression of FATP1 in the heart causes lipotoxic cardiomyopathy. Circ Res 2005, 96:225-233.

Mashek DG, Bornfeldt KE, Coleman RA, Berger J, Bernlohr DA, Black P, DiRusso CC, Farber SA, Guo W, Hashimoto N, Khodiyar V, Kuypers FA, Maltais LJ, Nebert DW, Singh I, Schaffer JE, Stahl A, Watkins PA, Vasiliou V, Yamamoto TT. Revised nomenclature for the long chain mammalian acyl-CoA synthetase gene family. J Lipid Res 2004, 45: 1958-1961.

Lee Y, Naseem RH, Duplomb L, Park BH, Garry DJ, Richardson JA, Schaffer JE, Unger RH. Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthetase transgenic mice. Proc Natl Acad Sci 2004, 101: 13624-13629.

Kwon G, Pappan KL, Marshall CA, Schaffer JE, McDaniel ML. Cyclic AMP dose-dependently prevents palmitate-induced apoptosis by both PKA- and cAMP-GEF-dependent pathways in beta-cells. J Biol Chem, 2004, 279:8938-8945.

Zhang J, Dudley-Rucker N, Crowley JR, Lopez-Perez E, Issandou M, Schaffer JE, Ory DS. The steroidal analog GW707 activates the SREBP pathway through disruption of intracellular cholesterol trafficking. J Lipid Res 2004, 45:223-231.

Schaffer JE. Lipotoxicity: when tissues overeat. Curr Opin Lipidol 2003, 14: 281-287.

Schaffer, J. The role of FATPs in fatty acid uptake. In: Duttaroy AK, Spener F, eds. Cellular Proteins and Their Fatty Acids in Health and Disease. Weinheim, Germany: Wiley-VCH, 2003, 31-38.

Frolov A, Zielinski SE, Crowley JR, Dudley-Rucker N, Schaffer JE, Ory DS. NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of LDL cholesterol-derived oxysterols. J Biol Chem 2003, 278:25517-25525.

Moulson CL, Martin DR, Lugus JJ, Schaffer JE, Lind AC, Miner JH. Spontaneous mutation of Slc27a4/fatty acid transport protein 4 results in wrinkle free mice. Proc Natl Acad Sci USA 2003, 100: 5274-5279.

Listenberger LL, Han X, Lewis SL, Cases S, Farese RV, Ory DS, Schaffer JE.  Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci USA 2003, 100: 3077-3082.

Richards MR, Listenberger LL, Lewis SE, Kelly AA, Ory DS, Schaffer JE. Oligomerization of the murine fatty acid transport protein 1 (FATP1). J Biol Chem 2003, 278: 10477-10483.

Listenberger LL, Schaffer JE. Mechanisms of lipoapoptosis: implications for human heart disease. Trends Cardiovasc Med 2002, 12:134-138.

Schaffer JE. Fatty acid transport: the roads taken. Am J Physiol 2002. 282: E239-E246. 

Meloni I, Muscettola M, Raynaud M, Longo I, Bruttini M, Moizard MP, Gomot M, Chelly J, desPortes V, Pryns JP, Ropers HH, Yntema HG, Lewis SE, Schaffer JE, Renieri, A. FACL4, encoding fatty acid ligase 4, is mutated in nonspecific X-linked mental retardation. Nat Genet 2002, 30: 436-440.

Souza SC, Muliro K, Liscum L, Lien P, Yamamoto MT, Schaffer JE, Dallal GE, Wang X, Kraemer FB, Obin M, Greenberg AS. Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system. J Biol Chem 2002, 277: 8267-8272.

Frolov A, Srivastava K, Daphna-Iken D, Traub LM, Schaffer JE, Ory DS. Cholesterol overload promotes morphogenesis of a Niemann-Pick C (NPC)-like compartment independent of inhibition of NPC1 or HE1/NPC2 function. J Biol Chem 2001, 276: 46414-46421. 

Lewis SL, Listenberger LL, Ory DS, Schaffer JE.  Membrane topology of the murine fatty acid transport protein 1 (FATP1). J Biol Chem 2001, 276: 37042-37050.

Chiu HC, Kovacs A, Ford DA, Hsu F-F, Garcia R, Herrero P, Saffitz JE, Schaffer JE.  A novel mouse model of lipotoxic cardiomyopathy. J Clin Invest 2001, 107: 813-22.

Listenberger LL, Ory DS, Schaffer JE.  Palmitate-induced apoptosis occurs through a ceramide-independent pathway. J Biol Chem 2001, 276: 14890-14895.

Millard EE, Srivastava K, Traub L, Schaffer JE, Ory DS. NPC1 overexpression alters cellular cholesterol homeostasis. J Biol Chem 2000, 275: 38445-51.

Stuhlsatz-Krouper SM, Bennett NE, Schaffer JE.  Molecular aspects of fatty acid transport: mutations in the IYTSGTTGXPK motif impair fatty acid transport protein function. Prostaglandins Leukot Essent Fatty Acids 1999, 60: 285-9.

Gargiulo CE, Stuhlsatz-Krouper SM, Schaffer JE.  Localization of adipocyte long-chain fatty acyl CoA synthetase at the plasma membrane. J Lipid Res 1999, 40:  881-892.

Stuhlsatz-Krouper SM, Bennett NE, Schaffer JE. Substitution of alanine for serine 250 in the murine fatty acid transport protein inhibits long chain fatty acid transport. J Biol Chem 1998, 273: 28642-50.

Hui TY, Smith AJ, Frohnert BI, Schaffer JE, Bernlohr DA. Characterization of the murine fatty acid transport protein gene and its insulin response sequence. J Biol Chem 1998, 273: 27420-9.

Man, MZ, Hui TY, Schaffer JE, Lodish HF, Bernlohr DA.  Regulation of the murine adipocyte fatty acid transporter gene by insulin.  Mol Endocrinology 1996, 10: 1021-8.

Schaffer JE.  A Novel Adipocyte Long Chain Fatty Acid Transport Protein. Eur J Med Res 1996, 1:176-80.

Schaffer JE, Lodish HF.  Molecular mechanism of long chain fatty acid uptake. Trends Cardiovasc Med 1995, 5:218-24.

Schaffer JE, Lodish HF.  Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell 1994, 79:427-36.

Aral SO, Schaffer JE, Mosher WE, Cates W. Gonorrhea rates: what denominator is most appropriate? Am J Public Health 1988, 78:702-703.

Weller SK, Spadaro A, Schaffer JE, Murray AW, Maxam AM, Schaffer PA. Cloning, sequencing and functional analysis of OriL, a Herpes Simplex type 1 origin of DNA synthesis. Mol Cell Biol 1985, 5:930-42.

Morimoto R, Schaffer, J, Meselson M. Transcription in vitro of Drosophila heat shock genes in HeLa cell-free extracts. In: Schlesinger MJ, Ashburner M, Tissières A, eds. Heat Shock: From Bacteria to Man. New York: Cold Spring Harbor Press 1982. 161-6.